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Over the four-year period, the percentage of female patients with a semaglutide or tirzepatide prescription who also had PCOS increased from 4.6% in 2021 to 5.7% in 2025, representing a 23.9% relative increase

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Funnel plots showed a symmetrical distribution of most SNPs around the central estimate, indicating the absence of significant directional pleiotropy or bias (Supplementary Figure S3)

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