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It mimics a naturally occurring hormone (GLP-1) that regulates appetite and blood sugar

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The GTP-bound alpha subunit can move away and activate downstream pathways, and the beta and gamma subunits can also dissociate and trigger complementary pathways

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Severe gastroparesis or significant gastrointestinal motility disorders also warrant avoidance as GLP 1 induced gastric emptying delays can worsen existing symptoms

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