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Since fibrosis is the most compelling predictor of outcomes, current and future therapies must focus on improving fibrosis by indirectly reducing pro-fibrotic inflammatory signaling or directly abrogating fibrosis

Chan notes that preserving and rebuilding lean muscle is critical for maintaining tone: Muscle acts like scaffolding beneath the skin

[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC

Although comparison studies with GLP-1 RA's have been conducted in the past, new doses have since been approved, making it difficult to compare tirzepatide to GLP-1 RA's based on previous studies

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efforts to preserve muscle