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All other authors declare that they have no conflicts of interest
In the STEP 2 trial, adults with obesity or overweight plus type 2 diabetes lost a mean 9.6% of their body weight at 68 weeks with semaglutide 2.4 mg vs

Common culprits include inadequate protein intake, insufficient sleep, excessive stress, and medication interactions
That research has demonstrated efficacy for weight management and glycemic control in specific study populations under controlled conditions

However, a personalised approach is appropriate when: Symptoms arise Weight loss is substantial Baseline nutritional status is uncertain High-risk groups are present Oversight should be proportional, not automatic

Ice crystals can form and physically shear the peptide chains
