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Independently of these peripheral actions, GLP-1RAs show direct cerebral effects in animal stroke models, such as reduction of infarct volume, apoptosis, oxidative stress, neuroinflammation, excitotoxicity, bloodbrain barrier permeability, and increased neurogenesis, neuroplasticity, angiogenesis, and brain perfusion

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Although dedicated trials of GLP-1RAs in AITD are lacking, preliminary reports suggest potential impacton thyroid volume, thyroid function, and autoimmune activity