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Pharmacological management of obesity: An endocrine society clinical practice guideline

[DOI] [PubMed] [Google Scholar] 56.Prez-Tilve D, Gonzalez-Matias L, Alvarez-Crespo M, Leiras R, Tovar S, Dieguez C, Mallo F

The clinical manifestations and severity of ileus present as: Complete inability to pass gas or have bowel movements, distinguishing it from simple constipation Severe abdominal distension causing visible swelling and extreme discomfort Intractable nausea and vomiting, including feculent vomiting in advanced cases Severe cramping and abdominal pain that worsens with attempted eating Dehydration and electrolyte imbalances from inability to absorb fluids Risk of intestinal perforation if pressure builds excessively Potential progression to sepsis and multi-organ failure without prompt treatment Need for nasogastric decompression, bowel rest, and potential surgical intervention The mechanism by which Ozempic causes ileus directly relates to its intended therapeutic action of slowing gastrointestinal motility, but in susceptible individuals, this effect becomes pathologically exaggerated

10.1016/S2213-8587(19)30249-9 39 LawrenceE
Data Availability Statement The datasets generated during and/or analyzed during this post hoc analysis are available from the corresponding author on reasonable request

Genetic engineering creates new opportunities In the early 1970s a new tool appeared on the scene called recombinant DNA technology or genetic engineering
