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However, UCP1 / mice did not lose weight beyond this time-point (Fig

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Patients on GLP-1 drugs showed improvement in heart health measures like A1C (a marker for diabetes) and blood pressure

The gene-set enrichment analysis was performed with the parameters exclude_iea set to true and correction method set to Benjamini-Hochberg

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3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%