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It can be most helpful for people who struggle with the GI-related side effects of these drugs, as well as those looking for more gradual weight loss or who want to taper off a GLP-1 without risking weight regain

In one study, nearly three-quarters of teens who received semaglutide experienced a weight loss of 5% or more compared with 18% of patients who experienced that degree of weight loss who received a placebo

Given these considerations, the therapeutic approach in older patients with T2D is complex, particularly in those who have functional dependence, frailty, dementia, or who are at end-of-life
FDA-approved weight management medications beyond GLP-1 agonists include: Phentermine-topiramate (Qsymia): Combination sympathomimetic and anticonvulsant showing 8-10% weight loss in clinical trials

Another potential strategy for managing rising costs is to increase employee cost sharing

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