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The other authors declare no conflicts of interest relevant to this paper

Subsequent studies demonstrated that apelin signaling is highly context dependent, with differential coupling to G_i, G_q, and -arrestin pathways depending on ligand structure, receptor density, and tissue environment (Murali and Aradhyam, 2023)

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de Munain, S

Common side effects include mild nausea, constipation, or temporary appetite reduction in the first 12 weekseffects that usually resolve as your body adapts

Examples: 16-year-old boy: BMI 27.5 (24.2 is 85th percentile) 16-year-old girl: BMI 29 (24.5 is 85th percentile) 17-year-old boy: BMI 28.4 (25.0 is 85th percentile) 17-year-old girl: BMI 29.5 (25.1 is 85th percentile) Exclusion or Contraindications GLP-1 therapy is not recommended for teens with: A personal or family history of medullary thyroid carcinoma or MEN2 A history of pancreatitis Severe gastrointestinal disease , such as gastroparesis or inflammatory bowel disease flare Current pregnancy or planning pregnancy Active eating disorder or untreated major psychiatric illness If your teen has any of these conditions, our providers will guide you toward safer, more appropriate options