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Por lo mencionado previamente, se ha propuesto que el manejo conjunto de metformina con prebiticos y probiticos puede reducir el riesgo de efectos adversos gastrointestinales, demostrndose en un ensayo controlado aleatorizado realizado por Dixon et al.57 que la administracin dual de prebiticos con metformina genera cambios favorables en el microbiota sin reducir los efectos adversos gastrointestinales

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( 10.1073/pnas.2110374119) [DOI] [PMC free article] [PubMed] [Google Scholar] 35.von Schnurbein J, Zorn S, Nunziata A, et al

Dulaglutide is administered via a pre-filled, single-dose pen, which simplifies dosing and may improve adherence

The goal is to give you a balanced view of whether semaglutide is a good choice for you as a runner, so you can decide if this option aligns with your fitness goals and health needs

Your body needs about 12 weeks to stabilize on the new timing, so you might notice slightly different appetite suppression during that window
