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Description
In the SUSTAIN-6 trial, injectable semaglutide demonstrated a notable effect in reducing the incidence of nonfatal stroke (hazard ratio [HR] 0.61
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Then came ACHIEVE-3 , published in The Lancet in February 2026, the first direct head-to-head comparison between two oral GLP-1 therapies
It needs to be reasonably lipid-soluble, because the outer skin layer is fatty
Mechanically, it slows down stomach emptying which also makes you feel more full after a meal
doi: 10.1136/tsaco-2018-000219
