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The regulatory landscape for compounded GLP-1 products has changed materially since early 2025, with the FDA resolving both semaglutide and tirzepatide shortages and ending temporary enforcement discretion periods
However, evidence in patients with prior pancreatitis is limited, which is why individualized medical judgment is essential

It boosts collagen and elastin production, smooths fine lines, and enhances healing at the cellular level

Neither form interferes with semaglutide

This is not a one size fits all scenario and reflecting No decision about me without me (Department of Health, 2012), the same considerations need to be applied in the PwDs decision to potentially not engage with this group GLP-1 RA start and opt for an individual one- to-one GLP-1 RA start instead.
