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Commercial plans vary significantly: some require BMI above 30, documented failed diet-and-exercise attempts lasting 6 months, or comorbidities like hypertension

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That restriction hasnt appeared to affect its popularity, though: Its already being used by as many as 400,000 people in the US, according to estimates from Wall Street firm Mizuho

This variation in treatment effect is suspected to be due to differences in medications, differences in methodology for lean mass assessment, and different lifestyle interventions prescribed in combination with pharmacological therapies [71]