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N Engl J Med 1990;322:10281031
It doesn't outperform injectables on raw weight loss numbers, but it removes a massive barrier for a large segment of the population
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A comprehensive meta-analysis, including SOUL trial data, demonstrated that long-acting GLP-1 RAs reduce the incidence of major adverse cardiovascular events (MACEs), hospitalization for heart failure, kidney events, and all-cause mortality in type 2 diabetes [66]
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In summary, the presence or absence of gastrointestinal symptoms cannot be used to diagnose or exclude the presence of delayed gastric emptying
