barriers to getting a glp-1 medication prescribed What say when requesting options: guide to your prescription Professor Randa Reda | New

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The results were striking: AHI reduction : Participants on tirzepatide saw their AHI decrease by roughly 50 to 60 percent compared to baseline

Abbreviations GLP-1: Glucagon-like peptide-1 GLP-1RA: Glucagon-like peptide-1 receptor agonist T2DM: Type-2 diabetes mellitus DPP-4: Dipeptidyl peptidase 4 HbA1c: Hemoglobin A1c NASH: Non-alcoholic steatohepatitis NAFLD: Non-alcoholic fatty liver disease Camp: Cyclic adenosine monophosphate PKA: Protein kinase A EPAC: Exchange protein directly activated by cAMP PI3K: Phosphoinositide 3-kinase PYY: Peptide YY CCK: Cholecystokinin GLUT4: Glucose transporter type 4 mTORC1: Mammalian target of rapamycin complex 1 References Ahrn B (2015) Hepato-incretin function of GLP-1: novel concept and target in type 1 diabetes

This table compares the active ingredients, FDA-approved usage, and typical weight loss or A1C reduction of some of the most well-known GLP-1s: Semaglutide vs tirzepatide Semaglutide is the active ingredient found in the injectable medications Ozempic and Wegovy (and the oral medication Rybelsus)

The trials also revealed non-inferior efficacy and a safety profile with that of the reference liraglutide

When we look at some of the key sources of whats driving that, its hard for me to create a story where those dynamics will go away and trends will come down, Guerriere said