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doi: 10.1016/S2213-8587(18)30024-X 23 FlintARabenAAstrupAHolstJJ

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Any potential advantage must be weighed against the well characterised adverse event profile of GLP-1 receptor agonistsincluding gastrointestinal intolerance, gallbladder disease, acute pancreatitis, and other adverse eventswithin a shared, patient centred decision making process that balances individual risk against potential additive gains.1 The observed epidemiological patterns in our study are highly consistent with the known pharmacology and neurobiological mechanisms of GLP-1 receptor agonists

most patients find this effect welcome Digestive changes constipation, loose stools, or mild bloating are common early on Fatigue occasionally reported in the first few weeks Injection site reactions mild itching or redness, typically resolves quickly Side effects are managed through gradual dose titration starting at a low dose and increasing slowly over several weeks