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Int J Obes Relat Metab Disord 25(5):622627

[DOI] [PMC free article] [PubMed] [Google Scholar] 38.Rai P., Madi M.Y., Dickstein A

GLP-1 receptor activation stimulates glucose-dependent insulin secretion, suppresses glucagon release, and slows gastric emptying in research models GIP receptor activation potentiates insulin secretion and modulates adipose tissue metabolism in preclinical studies Glucagon receptor partial agonism supports hepatic glucose output modulation and increased energy expenditure at physiological concentrations in research models The simultaneous engagement of all three receptors produces coordinated effects on insulin secretion, glucagon suppression, energy expenditure, and metabolic signaling studied in preclinical models and referenced in peer-reviewed literature

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