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Agents such as oral semaglutide, orforglipron, CagriSema, retatrutide and maridebart cafraglutide have achieved unprecedented mean weight reductions, often exceeding 15% to 20% of baseline body weight in clinical trials.37 Clinicians must keep in mind that pharmacotherapy alone is not a cure for obesity

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When to Seek Immediate Medical Attention Severe, persistent abdominal pain (possible pancreatitis) Vision changes or eye pain (possible retinopathy) Signs of severe dehydration (dizziness, dark urine, confusion) Allergic reaction (rash, difficulty breathing, swelling) Severe hypoglycemia (confusion, sweating, rapid heartbeat) Persistent vomiting lasting more than 24 hours GLP-1 drugs are being increasingly obtained by individuals without a prescription, which makes side effects more dangerous than ever

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This is a legitimate clinical concern, but the solution involves dose optimization with a healthcare providernot independent schedule changes

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There are very few studies available assessing the utility of PET stress testing in patients with MB

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