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When semaglutide patients switch to tirzepatide In the graph below, you can see that patients who switched from semaglutide to tirzepatide, either because of greater side effects on semaglutide or because they felt they hit a plateau on semaglutide, they continued to lose weight on tirzepatide

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This practice has been discussed in medical literature as a potential strategy to enhance tolerability, particularly for patients with severe gastrointestinal (GI) side effects common with GLP-1 receptor agonists, by allowing slow, incremental adjustments