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Whereas the STEP 1 trial delivered semaglutide with wrap around care

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While uncomfortable, thirst rarely prevents patients from continuing treatment, as symptoms typically improve and can be effectively managed

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An expert explains what the evidence really says

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At 1 year, the treatment group had a mean BMI increase of 4.6%, and the placebo groups BMI increased 10.1%

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No peer-reviewed trials support simultaneous administration, and regulatory guidance classifies such use as off-label and potentially unsafe without explicit physician oversight and patient consent

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That is the legitimate path for anyone looking at this class of treatment right now

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