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Whereas the STEP 1 trial delivered semaglutide with wrap around care

While uncomfortable, thirst rarely prevents patients from continuing treatment, as symptoms typically improve and can be effectively managed

An expert explains what the evidence really says

At 1 year, the treatment group had a mean BMI increase of 4.6%, and the placebo groups BMI increased 10.1%

No peer-reviewed trials support simultaneous administration, and regulatory guidance classifies such use as off-label and potentially unsafe without explicit physician oversight and patient consent

That is the legitimate path for anyone looking at this class of treatment right now
