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Several mechanisms may potentially contribute to blood pressure effects, including: weight loss (a well-established factor in blood pressure reduction), possible promotion of natriuresis (sodium excretion by the kidneys), and theoretical improvements in endothelial functionthough many of these mechanisms remain hypothetical rather than definitively proven

The study also built a combined prediction model using genetics alongside demographic and clinical factors (age, sex, BMI, drug type, T2D status, and others)

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Both types of medications effectively lower blood glucose, but long-acting drugs may dominate the market due to higher patient compliance

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