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As fat tissue decreases, the support structures around the bladder and urethra adjust, and this transition period can temporarily weaken continence control
Nationwide retrospective studies utilizing register data from Sweden and Denmark (20132021) and the UK CPRD (20072020) have revealed consistent findings, indicating that GLP-1 RAs are not associated with an elevated risk of suicidality relative to DPP-4 or SGLT-2 inhibitors [77,78]

A comparative analysis found that non-diabetic patients with obesity on tirzepatide had a 64% lower risk of developing new-onset gastroparesis compared to those on semaglutide
That is a significant clinical observation
Additionally, Rybelsus doesnt perform as well as its injectable counterpart, even at this higher dosage