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Serious Side Effects and When to Contact a Provider Serious side effects are uncommon, but medical guidance is important if you experience: Severe or persistent abdominal pain Ongoing vomiting Signs of dehydration such as confusion or minimal urination Symptoms of low blood sugar, including shakiness, sweating, or rapid heartbeat Prompt communication with your provider helps prevent complications

This early response varies based on starting dosethose beginning at lower doses may experience a gentler onset, while standard initiation doses produce more immediate effects

Semaglutide is often well tolerated

The label expansion was supported by two Phase III trialsa 12-week induction study and a 52-week maintenance studyboth of which met the primary endpoint of clinical remission