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Dual GLP-1/glucagon receptor agonists, including mazdutide, integrate appetite suppression with increased energy expenditure and fat oxidation, while triple GLP-1/GIP/glucagon agonists, such as retatrutide, further augment these mechanisms through multi-pathway receptor engagement

However, individual response varies based on genetics, baseline metabolism, and adherence

For example, one of the most notable trials on the subject is the ELAD trial, which stands for Evaluating Liraglutide in Alzheimer's Disease. This 12-month RCT reported that liraglutide improves cognitive function and MRI volume in the temporal lobe and whole cortex, suggesting a potential benefit in treating Alzheimer's [21]

Furthermore, GLP-1 controls gastric emptying, motility, colonic transit time, satiety action, energy expenditure, and thermogenesis32,33,34)

Tirzepatide, a dual GIP/GLP-1 receptor agonist, is effective and safe when added to basal insulin for treatment of type 2 diabetes (SURPASS-5)

Expert Perspective After supporting peptide researchers for many years, one lesson continues to stand out: Successful experiments begin long before the first sample is prepared