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More research is required to determine the long-term safety and efficacy of both drugs.

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Beyond that, data is still accumulating, but current evidence shows no safety signals that would contradict indefinite use for most patients

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Cardiovascular outcomes trials, if initiated, would address the key data gap relative to Metformin

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As we continue to ride the wave of GLP-1 agonists, several vital areas warrant further investigation: Longitudinal studies must assess long-term cognitive outcomes to understand the drugs impact on cognitive function over extended periods

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