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More research is required to determine the long-term safety and efficacy of both drugs.

Beyond that, data is still accumulating, but current evidence shows no safety signals that would contradict indefinite use for most patients

Cardiovascular outcomes trials, if initiated, would address the key data gap relative to Metformin

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As we continue to ride the wave of GLP-1 agonists, several vital areas warrant further investigation: Longitudinal studies must assess long-term cognitive outcomes to understand the drugs impact on cognitive function over extended periods
