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Activation of GLP-1R reduced NTG-induced c-fos expression in the TNC In addition to CGRP, we also detected alterations in c-fos expression in the TNC, which is a reliable marker of neuronal activation and is considered another mediator of central sensitization

Improved solid-phase peptide synthesis methods, better purification techniques, and economies of scale as production volumes increase all contribute to gradually declining manufacturing costs

In this context, the functional mimicry of GLP-1 should be considered worthwhile if the designed agonist can act as a biased agonist of GLP-1R, selectively triggering anti-inflammatory signaling pathways that can aid in reducing the growth and differentiation of certain types of neuroendocrine tumors