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These side effects are typically mild to moderate in severity and tend to improve over time

Importantly, when patients stop semaglutide, the weight they regain tends to be mostly fat mass not lean mass, leaving them potentially worse off in terms of joint support and musculoskeletal health

J Neurochem 124 : 808820

Effect of porcine gastric inhibitory polypeptide on beta-cell function in type I and type II diabetes mellitus

References 1.American Psychiatric Association

PLoS ONE 11(10):e0163907 Bjornstad P, Hughan KS, Kelsey MM, Shah A, Lynch JL, Nehus E et al (2019) 123-OR: effect of surgical vs medical therapy on diabetic kidney disease (DKD) in severely obese adolescents with type 2 diabetes (T2D)