glp-1 receptor agonist contraindications to glp 1 glp 1 agonists contraindications Agonists, What Do I Need to Know? glp-1_analogs [TUSOM | Pharmwiki]

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Intravenous infusion of GLP-1 for 48 h in healthy human subjects increased muscle sympathetic nerve activity but had no effect on BP, norepinephrine plasma concentration, or the sympathetic/parasympathetic balance as estimated by the HR variability, suggesting that the increase in sympathetic drive is at least partially compensated by an increase in the parasympathetic activity [53]

However GIP did not show efficacy in diabetic patients so the search continued (1)

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