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Description
Risk of bias was assessed using an adapted Quality Assessment Tool for In Vitro Studies (QUIN) tool
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In most major obesity trials, GLP-1 therapy was: Escalated to high or maximum tolerated doses Stopped abruptly, not down-titrated Followed by little or no continuation of structured lifestyle support In the STEP-1 extension trial (semaglutide 2.4 mg), participants who discontinued therapy regained approximately two-thirds of their prior weight loss over the following year
The move targets insured patients as competition with Eli Lillys Zepbound heats up.
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