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The two classes protect different organs by different mechanisms: SGLT2 inhibitors push glucose out through the urine and have strong heart-failure and kidney data behind them, while GLP-1 drugs work on insulin release, appetite, and the arteries

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Hikma Pharmaceuticals Hikma is working on generic versions and biosimilars of GLP-1 drugs to improve accessibility and affordability in developing markets

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In natural physiological conditions, KB levels remain low in healthy adults ( 3.0.CO;2-8

In receptor binding studies, it has been shown to have a GLP-1R and GLP-1 binding affinity, respectively, about five times lower than that of native and similar to endogenous GIP (40)