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Of note, evidence suggests that even small reductions in HbA1c can improve cardiovascular outcomes in overweight or obese individuals without diabetes, similar to the population in this Study

10.3892/etm.2019.7347 107 WangL.LiP.TangZ.YanX.FengB

The EM structures (Figure 2b) of the receptor revealed that it is composed of: The extracellular domain (E) of the GLP-1 receptor binds the GLP-1 protein A seven transmembrane helical domain (TM1-7) with the -helices separated by three intracellular loops (IC1-3) and three extracellular loops (EC1-3) An intracellular (Cytoplasmic) C-terminus that interacts with G-Protein which is responsible for signaling The extracellular domain: The N-terminal ~120 amino acids of the extracellular domain of the GLP-1R protein has one long and one short helix, two beta strands forming a sheet and several loops joining these secondary structural elements

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Przybyszewska J et al

53, e12763