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A reasonable starting framework, based on extrapolation from GLP-1 nasal delivery literature, might look like this: Conservative approach: Begin with 0.5-1mg per nasal actuation, administered once daily

doi: 10.1016/j.neurobiolaging.2012.04.009 53 KellyPMcCleanPLAckermannMKonerdingMAHlscherCMitchellCA

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The active semaglutide peptide has partially degraded, meaning each dose delivers less medication than the label indicates

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While treatment with a particular inhibitor of miR-7 dramatically enhanced cAMP synthesis, miR-7 had a substantial negative effect on GLP-1-induced cAMP levels [167]