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For others, they can be severe

These medicines are made with no regard for safety and pose serious risks

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16 GLP-1 receptors are found in key brain regions that handle cognition and energy metabolism, including the neocortex, hippocampus, and hypothalamus

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Inoltre, la disestesia stata segnalata anche in studi come OASIS 1, in cui la formulazione orale del farmaco determina unesposizione plasmatica di picco molto pi alta rispetto alla formulazione sottocutanea a parit di effetto sulla perdita di peso (Knop et al., 2023), suggerendo che sia il profilo di esposizione e non la variazione ponderale a guidare il fenomeno