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Similar to AD, the prevalence of PD increases with age and is expected to increase with population aging [7]

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However, evidence for the beneficial effect of physical activity on improved cognitive function in people living with one or more types of dementia is not universally demonstrated (Brasure et al., 2017), and methodological limitations common to the study of nonpharmacological approaches limit the ability to make conclusions on causality and level of effect

In the proximal tubule, the activation of GLP1-R leads to the onset of the cAMP signaling cascade with phosphorylation of NHE3 (Na + /H + exchanger isotope 3) and reduction of its function
