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This background sets the stage for a detailed exploration of semaglutides mechanisms and clinical evidence in HFpEF

In-class differences were noticed especially related to heart failure (HF) and are discussed later in this manuscript

Avoid extreme temperatures and humidity
Appetite and Satiety Support GLP-1 receptor agonists work in part by slowing gastric emptying and enhancing satiety signals, which may support earlier feelings of fullness and reduced energy intake
