surpass tirzepatide Efficacy and safety of monotherapy compared with dulaglutide in Japanese patients with type 2 diabetes (SURPASS J-mono): a double-blind, multicentre, randomised, phase 3 trial Post Hoc Analysis of SURPASS-1

A more mindful, wellness-forward approach to GLP-1 use

Both medications carry warnings about thyroid tumors based on animal studies

On the other hand, levels of other lipids, including cardiolipins, which play a pivotal role in mitochondrial metabolism, were increased after dulaglutide treatment

14 That is, high rates of decline in PPD are possible regardless of the initial PPD levelfor example, the Republic of Korea had the most rapid improvement in PPD from a low initial PPD while Tanzania also had a rapid improvement in PPD despite a high initial level (table 1)

Furthermore, an important reduction in the number of deaths due to stroke was observed in the semaglutide treatment group (RR 0.49

These results establish tirzepatide as an effective standalone therapy, reducing the clinical rationale for risky combination approaches