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Getting it at baseline provides a more complete picture of your metabolic health and helps quantify your response to GLP-1 treatment over time

I believe these medications have such broad effects because a lot of health problems begin with disruptions in insulin resistance [abnormalities in how the body handles glucose] and inflammation, says Jamy Ard, MD, a professor of epidemiology and prevention at Wake Forest University School of Medicine in Winston-Salem, North Carolina

That is especially important in treatment areas where real-world use is evolving rapidly

Similar unpublished preclinical data on file at Merck has been summarized (35)

The reactions lead to the activation of other pancreatic zymogens such as chymotrypsinogen, proelastase, prophospholipase, and procarboxypeptidases that are necessary for digestion

In many cases, employer-sponsored health plans exclude weight-loss medications altogether, even when obesity-related conditions significantly impact overall health outcomes