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However, current clinical trials have not shown a significant difference in side effect rates between GIPR/GLP-1R dual agonist and GLP-1RA alone

[DOI] [PMC free article] [PubMed] [Google Scholar] 10.Lisco G., Bartolomeo N., De Tullio A., De Pergola G., Guastamacchia E., Jirillo E., Piazzolla G., Triggiani V., Giagulli V.A

These findings suggest that survodutide has the potential to reduce liver fibrosis and improve liver function in patients with NASH, making it a promising therapeutic option for this complex liver disease [89]

We havent had a good treatment for metabolic-associated liver disease, and so this is something which actually can help reduce visceral fat accumulation. However, because GLP-1 drugs are still fairly new in widespread use, some questions remain

Consequently, patients with T2DM often exhibit reduced Pdx1 expression levels (Ofori et al., 2022)

However, this landscape could shift next year with the anticipated approval of: The oral version of Wegovy for obesity treatment (approved just yesterday) Eli Lillys Orforglipron
