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However, discontinuing the medication entirely often leads to weight regain because GLP-1s address physiological drivers of hunger and metabolism that persist even after weight loss

GLP1-Agonisten bei Hautleiden: Hoffnung oder Hype

The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) potentiate meal-stimulated insulin secretion through direct and indirect actions on islet -cells

References Renal tubular effects of prolonged therapy with the GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes mellitus

Studies reporting metabolic outcomes were the most common