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[DOI] [PMC free article] [PubMed] [Google Scholar] 256.Swift D.L., McGee J.E., Earnest C.P., Carlisle E., Nygard M., Johannsen N.M

DPP-4 also cleaves cytokines and chemokines, contributing to inflammation [11]

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The effect of substitution on binding affinity (GLP-1 radioligand competition IC 50 ) and potency (cAMP activity EC 50 ) was, however, much larger for Phe 28 (1300/1000-fold decrease in affinity/potency) and Ile 29 (93/27-fold reduction) compared with Leu 32 (17/twofold decrease), indicating that interactions of Phe 28 and Ile 29 with the conserved hydrophobic core of the ECD of GLP-1R are particularly important (Adelhorst et al., 1994)

The mechanism by which tirzepatide contributes directly to reduced cardiorenal risk is an area that requires additional investigation

DOI: 10.1111/dom.15728