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Reports of alopecia (6.9% vs 0.3%) were higher in patients who received 50 mg oral semaglutide weekly than in those on placebo, but only 0.2% of patients on 2.4 mg of subcutaneous semaglutide reported alopecia vs 0.5% of those on placebo

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Elderly patients may experience differential responses to GLP-1R agonists due to age-related changes in GLP1R expression, tumor microenvironment, and systemic physiology