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This activates protein kinase A (PKA), which phosphorylates the sulfonylurea receptor-1 (SUR1) subunit of the K + /ATPase channel, leading to early closure of this channel and an amplified physiological Ca 2+ influx via voltage-gated calcium channels

Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes N Engl J Med

Drucker, D., Easley, C

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3 min read It seems like everyone and their uncle wants to get their hands on GLP-1 drugs like Ozempic for weight loss

Together, these scenarios highlight that cold chain precision is essentialnot optionalwhen shipping GLP-1 medications