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two malignancies strongly linked to obesity and hyperinsulinemia

C.NeefC.van den BerghJ

Here is the framework

59,60 In addition to its intrinsic effects on the enteric nervous system, glucose in the lumen of the gastrointestinal tract causes neuronal activation in vagus nerve afferents, the nucleus tractus solitarius, the arcuate hypothalamic nucleus and the dorsal motor nucleus, thus highlighting the role of brain circuitry in vagus nerve regulation of gastrointestinal function and pancreatic secretion

A combination approach works best

We do not have a good handle on GLP-1 receptor agonists and their impact on systemic levels of oral contraceptives