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Patients who stop the medication typically see weight return over time, which is consistent with the clinical understanding that these medications address biological drivers of appetite rather than "curing" the underlying condition

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Diarrhea, nausea, and other digestion-related side effects are very common when you first start taking Janumet or Janumet XR

[DOI] [PubMed] [Google Scholar] 1337.Inzucchi SE

If you are wondering when the "magic" happens, here is a realistic timeline of what occurs in your body from the first hour to the first year

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