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Inhibition of SGLT-1 in the small intestine causes more glucose transport to the distal intestine and colon, resulting in greater fermentation of glucose to SCFAs by luminal bacteria and increased sustained release of GLP-1 in the distal intestine [174] (Fig

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LincoffAMBrown-FrandsenKColhounHMDeanfieldJEmersonSSEsbjergSet alSemaglutide and cardiovascular outcomes in obesity without diabetes

GLP-1 signalling slows gastric emptying and blunts appetite centrally