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Description
MAPKs, particularly the extracellular regulated protein kinase 1/2 (ERK1/2), are associated with the leptin signaling [135, 136]

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Regular moderate exercise supports hormonal balance, though excessive exercise combined with rapid weight loss can exacerbate menstrual irregularities
Phase 3 trials (the TRIUMPH programme, registered on ClinicalTrials.gov) are currently underway, evaluating retatrutide across broader populations including those with cardiovascular disease, type 2 diabetes, and obesity-related complications

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