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This does not definitively establish that tirzepatide cannot affect sleep in some individuals, as clinical trials may not capture all potential effects, particularly those that occur at low frequencies or emerge during longer-term use

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The Expanding Role of GLP-1 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health
Cell, 153(6), 11941217

57 , 168 These approaches can be problematic as high doses are not clearly defined, and because of a lack of tachyphylaxis to gastric emptying effects, short-acting GLP-1 RAs affect gastric emptying more than the long-acting ones
