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Which HRT delivery methods are affected Affected by GLP-1 medications (oral delivery): Oral estrogen tablets (conjugated equine estrogens, estradiol) Oral progesterone (micronized progesterone, such as Utrogestan) Oral progestins (norethisterone, medroxyprogesterone) Oral testosterone (testosterone undecanoate) NOT affected by GLP-1 medications (non-oral delivery): Transdermal estrogen patches Topical estrogen gels and creams Vaginal estrogen rings or suppositories Progesterone-releasing IUD (Mirena) Transvaginal progesterone Testosterone injections Testosterone pellets Testosterone patches or gels The distinction is simple

Slopes for AP and NTS are significantly different (p = 0.0202)

Weeks 1 to 4: Starting at 2.5 mg Your first four weeks happen at 2.5 mg once weekly

P6s PHQ-9 score reduced from 12 to 4, i.e

A reasonable physician would want that distinction communicated clearly to any patient considering either option

If it has been at least 30 days since the first day of your last period, you should consider a lab-quality pregnancy test from a health clinic