shortage of glp-1 receptor agonists says DHSC GLP-1 receptor agonists (GLP-1RAs): cardiovascular

doi: 10.1056/NEJMoa2108269 16 DaviesMJD'AlessioDAFradkinJKernanWNMathieuCMingroneGet al

503,512,518 These effects include modulating cell proliferation, inflammation, and oxidative stress in liver cells, all of which are key factors in the development and progression of HCC

40 However, the improvement in peak VO 2 was within the margin of measurement error and was not accompanied by a corresponding improvement in the 6MWT distance or quality of life, so this finding needs to be investigated further

W.(2015) Inhibition of Dipeptidyl Peptidase 8/9 Impairs Preadipocyte Differentiation

This physiologic effect helps regulate postprandial glucose excursions and contributes to satiety and weight loss

What the Phase 3 doses tell us The Phase 3 maintenance doses of 4mg, 9mg, and 12mg represent a refinement of the Phase 2 protocol