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NICE recommends a stepwise approach including dietary modifications (low FODMAP diet), regular physical activity, stress management, and symptom-specific medications such as loperamide for diarrhoea, linaclotide for constipation, and antispasmodics for abdominal pain

Patients with certain genetic profiles may need slightly higher doses or benefit from dual-compound therapy like GLP-Squared to achieve optimal hunger suppression

they stopped, in other words, because the drug was too effective

validation, E.O.A., B.A.A., M.M.I., M.S.F

FDA/EMA guidance on nanomedicines)

It's not yet clear how fibers achieve this, but the authors of the review suspect that they increase the release of gut hormones, like GLP-1, thereby stimulating insulin and suppressing appetite